abstract：:Traumatic spinal cord injury (SCI) is a major cause of death and lifelong disability in the world. However, the pathological process of SCI has not been fully understood. F-box/WD repeat-containing protein 5 (FBXW5), a subunit of the SCF-type E3 ubiquitin ligase complex, plays an essential role in regulating various p...

journal_title：Biochemical and biophysical research communications

authors： Zhao P,Chao W,Li W

更新日期：2019-06-25 00:00:00

abstract：:Excessive oxidative stress induces significant injury and cytotoxicity to neuronal cells. The current study tested expression and the potential function of the circular RNA PRKCI (circPRKCI) in oxidative stress-injured neuronal cells. In cultured SH-SY5Y neuronal cells, hydrogen peroxide (H2O2) downregulated circPRKCI...

journal_title：Biochemical and biophysical research communications

authors： Cheng Q,Cao X,Xue L,Xia L,Xu Y

更新日期：2019-06-25 00:00:00

abstract：:TANC1 and its close relative TANC2 are two important synaptic scaffold proteins which play critical roles in regulating densities of synaptic spines and excitatory synapse strength. Recent studies indicated TANC1 and TANC2 are candidate genes of several neurodevelopmental disorders (NDD). So far, the biochemical prope...

journal_title：Biochemical and biophysical research communications

authors： Yang Q,Liu H,Li Z,Wang Y,Liu W

更新日期：2019-06-25 00:00:00

abstract：:Endothelial dysfunctions, such as pyroptosis, are chronic inflammatory processes with important roles in atherosclerosis. Adiponectin (APN), an adipocyte-derived protein that is abundant in circulation, reportedly protects against atherosclerosis. However, the mechanism underlying its antiatherogenic effect on human a...

journal_title：Biochemical and biophysical research communications

authors： Zhang L,Yuan M,Zhang L,Wu B,Sun X

更新日期：2019-06-18 00:00:00

abstract：:Helicobacter pylori is a pathogenic flagellated bacterium that infects the gastroduodenal mucosa and causes peptic ulcers in humans. FliD caps the distal end of the flagellar filament and is essential in filament growth. Moreover, FliD has been studied to diagnose and prevent H. pylori infection. Here, we report struc...

journal_title：Biochemical and biophysical research communications

authors： Cho SY,Song WS,Oh HB,Kim HU,Jung HS,Yoon SI

更新日期：2019-06-18 00:00:00

abstract：:Long noncoding RNA (lncRNAs) UCA1 has been known to be critical for the chondrogenic differentiation of marrow mesenchymal stem cells (MSCs). In this study, we explore the effects and mechanisms of UCA1 on the promotion of chondrogenesis of MSCs. During the processes of chondrogenic differentiation of MSCs, UCA1, miRN...

journal_title：Biochemical and biophysical research communications

authors： Shu T,He L,Wang X,Pang M,Yang B,Feng F,Wu Z,Liu C,Zhang S,Liu B,Wang Q,Rong L

更新日期：2019-06-18 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been reported as essential regulators in human cancers, including lung adenocarcinoma (LUAD). In the present study, we found that lncRNA long intergenic non-protein coding RNA 467 (LINC00467) was expressed higher in TCGA LUAD samples and predicted poor prognosis in LUAD patients. Hi...

journal_title：Biochemical and biophysical research communications

authors： Yang J,Liu Y,Mai X,Lu S,Jin L,Tai X

更新日期：2019-06-18 00:00:00

abstract：:Ovarian cancer (OC) is one of the most prevalent cancers with high fatality rate. In the present study, RT-PCR showed that the mRNA level of CDKN2B-AS1 was significantly upregulated while the miR-411-3p was downregulated in OC cell lines. In addition, the Sh-CDKN2B-AS1 resulted in the suppression of cell growth, invas...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Huang Y,Liu H,Su D,Luo F,Zhou F

更新日期：2019-06-18 00:00:00

abstract：:Protein synthesis and degradation balance have a crucial role in maintenance of cellular homeostasis and function. The ubiquitin-proteasome system is one of the major cellular proteolytic machineries responsible for the removal of normal, abnormal, denatured or in general damaged proteins. Proteasome is a multisubunit...

journal_title：Biochemical and biophysical research communications

authors： Sakellari M,Chondrogianni N,Gonos ES

更新日期：2019-06-18 00:00:00

abstract：:Extracellular vesicles (EVs) play an important role in biological functions and may feature innate therapeutic potential for diseases. In the present study, EVs released by osteoblasts at different stages of the mineralization process were investigated for their potential ability to promote bone formation. Results sho...

journal_title：Biochemical and biophysical research communications

authors： Wei Y,Tang C,Zhang J,Li Z,Zhang X,Miron RJ,Zhang Y

更新日期：2019-06-18 00:00:00

abstract：:Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders and is characterized by impaired attention, hyperactivity, and impulsivity. While multiple etiologies are implicated in ADHD, its underlying mechanism(s) remain unclear. Although previous studies have suggested dysre...

journal_title：Biochemical and biophysical research communications

authors： Nguyen Nguyen HT,Kato H,Sato H,Yamaza H,Sakai Y,Ohga S,Nonaka K,Masuda K

更新日期：2019-06-11 00:00:00

abstract：BACKGROUND:Lipopolysaccharide (LPS)-induced macrophage/monocyte activation and pro-inflammatory cytokines production are important mediators for periodontitis progression. The current study tested the potential role of insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in the process. METHODS:THP-1 human ma...

journal_title：Biochemical and biophysical research communications

authors： Xie J,Li Q,Zhu XH,Gao Y,Zhao WH

更新日期：2019-06-11 00:00:00

abstract：:Microglia are central nervous system-resident immune cells that play a crucial role in brain development by interacting with neural precursor cells (NPCs). It has been reported that microglia regulate the number of NPC by phagocytosis, inducing apoptosis, and promoting proliferation. Microglia surrounding the subventr...

journal_title：Biochemical and biophysical research communications

authors： Yamamiya M,Tanabe S,Muramatsu R

更新日期：2019-06-11 00:00:00

abstract：:In rice, Hd3a, GF14 and OsFD1 proteins, forming florigen activation complex, are key components in flowering time regulation. GF14 genes in rice response to biotic and abiotic stress has also been well addressed. The role of GF14e in rice defense has been well studied. However, whether Hd3a and OsFD1 play roles in def...

journal_title：Biochemical and biophysical research communications

authors： Ke Y,Wu M,Zhang Q,Li X,Xiao J,Wang S

更新日期：2019-06-11 00:00:00

abstract：:The development of adipose tissue is a precisely coordinated cellular process, in which both protein-coding and non-coding genes are involved. To characterize the in vivo function of a novel long non-coding RNA (lncRNAs), loss-of-function assays were performed with slincRAD knockdown mice. Down-regulation of slincRAD ...

journal_title：Biochemical and biophysical research communications

authors： Zhang P,Bai H,Li J,Liu J,Ma W,Xu B,Xia Q,Wang J,Fan Yi,Du Q

更新日期：2019-06-11 00:00:00

abstract：:Efonidipine is a dual L-/T- type calcium channel blocker with a slow onset of action and a long lasting effect that exibihits antihypertensive and nephroprotective effects. differs from most other DHPs which can induce reflex tachycardia. Efonidipine reduces blood pressure without decreasing cardiac output and exerts ...

journal_title：Biochemical and biophysical research communications

authors： Xu F,Xiong W,Huang Y,Shen J,Zhou D,Tang L

更新日期：2019-06-04 00:00:00

abstract：:Streptococcus pneumoniae is a pathogenic bacterium that can cause severe invasive diseases, such as pneumonia, otitis media and meningitis. The pro-inflammatory cytokine, IL-1β, has been reported to play important role in host defense against S. pneumoniae. The mechanism of IL-1β maturation and secretion in macrophage...

journal_title：Biochemical and biophysical research communications

authors： Zhang T,Du H,Feng S,Wu R,Chen T,Jiang J,Peng Y,Ye C,Fang R

更新日期：2019-06-04 00:00:00

abstract：:Mutations of the microtubule (MT)-associated protein Doublecortin X (DCX) gene disrupt cortical layering in brain development. Whilst many of these pathogenic DCX mutations are within the doublecortin domains (DC1 and DC2) that mediate direct DCX-MT association, a pathogenic mutation DCX E2K that causes cognitive impa...

journal_title：Biochemical and biophysical research communications

authors： Moslehi M,Ng DCH,Bogoyevitch MA

更新日期：2019-06-04 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a prevalent malignancy with increasing incidence and extremely poor prognosis worldwide. The multi-kinase inhibitor sorafenib is widely used as a first-line systematic treatment agent of advanced hepatocellular carcinoma. However, the benefit of sorafenib in clinical treatment is ofte...

journal_title：Biochemical and biophysical research communications

authors： Long Q,Zou X,Song Y,Duan Z,Liu L

更新日期：2019-06-04 00:00:00

abstract：:Recurrent osteosarcoma is a chemotherapy-resistant disease. Individualized precision therapy is needed for this disease. Toward this goal, we have developed the patient-derived othotopic xenograft (PDOX) mouse model of all major cancer types including osteosarcoma. Synergistic efficacy of trabectedin (TRAB) and irinot...

journal_title：Biochemical and biophysical research communications

authors： Higuchi T,Miyake K,Oshiro H,Sugisawa N,Yamamoto N,Hayashi K,Kimura H,Miwa S,Igarashi K,Chawla SP,Bouvet M,Singh SR,Tsuchiya H,Hoffman RM

更新日期：2019-05-28 00:00:00

abstract：:Deinococcus radiodurans is an extremophilic bacterium well-known for its extraordinary resistance to ionizing radiation and other DNA damage- and oxidative stress-generating agents. In addition to its efficient DNA damage repair and oxidative stress resistance mechanisms, protein family expansions and stress-induced g...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Zhao L,Seo HS,Jung JH,Choi JI,Kim MK,Lim S

更新日期：2019-05-28 00:00:00

abstract：:Tissue nicotinamide adenine dinucleotide (NAD+) decline has been implicated in aging. We have recently identified CD38 as a central regulator involved in tissue NAD+ decline during the aging process. CD38 is an ecto-enzyme highly expressed in endothelial and inflammatory cells. To date, the mechanisms that regulate CD...

journal_title：Biochemical and biophysical research communications

authors： Chini C,Hogan KA,Warner GM,Tarragó MG,Peclat TR,Tchkonia T,Kirkland JL,Chini E

更新日期：2019-05-28 00:00:00

abstract：OBJECTIVE:Inflammatory bowel diseases (IBD) including ulcerative colitis and Crohn's disease are devastating diseases of the gut. At present, all the treatments are mainly targeting symptoms like inflammation. The disease remains regarded as incurable, largely due to lacking of knowledge on its etiology. Our previous s...

journal_title：Biochemical and biophysical research communications

authors： He Y,Yu H,Ge Y,Li X,Jiang M,Liu Y,Li X,Wang Y,Guo M,Qin X,Wang X

更新日期：2019-05-28 00:00:00

abstract：:MOTS-c, as a mitochondria derived peptide, exerts benefits for insulin resistance in HFD mice and against various stresses in an AMPK dependent way. Here, in the D-galactose chronic injection models, exogenous MOTS-c was given to determine its direct anti-aging effects. The body weight, insulin sensitivity and blood g...

journal_title：Biochemical and biophysical research communications

authors： Li Q,Lu H,Hu G,Ye Z,Zhai D,Yan Z,Wang L,Xiang A,Lu Z

更新日期：2019-05-28 00:00:00

abstract：:Dysfunction of Girdin plays a crucial role in the development of a variety of tumors. Phosphorylated regulation of Girdin has been studied extensively. However, how Girdin is dephosphorylated remains unclear. In this study, we report a mechanism of Girdin dephosphorylation and the importance of this mechanism in the m...

journal_title：Biochemical and biophysical research communications

authors： Li J,Enomoto A,Weng L,Sun L,Takahashi M

更新日期：2019-05-21 00:00:00

abstract：:Genetic predisposition is necessary for polycystic kidney disease (PKD) initiation, although there are other, incompletely identified downstream processes that are required for cyst growth. Their characterization may provide a unique opportunity for clinical interventions. One of the poorly studied phenomena in PKD is...

journal_title：Biochemical and biophysical research communications

authors： Arkhipov SN,Pavlov TS

更新日期：2019-05-21 00:00:00

abstract：:Vascular pericytes and smooth muscle cells surround many blood vessels of the body. Their primary roles include vessel stabilization and regulation of the blood flow. The high degree of heterogeneity among these cells is dictated by (1) differences in their developmental origin and (2) their location in the vascular b...

journal_title：Biochemical and biophysical research communications

authors： Halaidych OV,Mummery CL,Orlova VV

更新日期：2019-05-21 00:00:00

abstract：:Rare cold-inducible 2 (RCI2) proteins are small hydrophobic proteins that are known to be localized in cellular membranes. The function of RCI2 proteins has been reported to be associated with low-temperature, salt, and drought stress tolerances as a membrane potential regulator; however, the specific functions are st...

journal_title：Biochemical and biophysical research communications

authors： Kim HS,Park W,Lim HG,Eom S,Lee JH,Carlson JE,Ahn SJ

更新日期：2019-05-21 00:00:00

abstract：BACKGROUND:Numerous previous studies have revealed that many long non-coding RNAs (lncRNAs) are upregulated in gastric cancer (GC) and are associated with tumor onset and progression in GC. ADPGK-AS1, a novel lncRNA, has been discovered as an oncogenic lncRNA in pancreatic cancer while its function in GC remains unclea...

journal_title：Biochemical and biophysical research communications

authors： Huang Z,Yang H

更新日期：2019-05-21 00:00:00

abstract：:Voltage-gated potassium (K+) channel sub-family B member 1 (KCNB1, Kv2.1) is known to undergo oxidation-induced oligomerization during aging but whether this process affects brain's physiology was not known. Here, we used 10, 16 and 22 month-old transgenic mice overexpressing a KCNB1 variant that does not oligomerize ...

journal_title：Biochemical and biophysical research communications

authors： Yu W,Zhang H,Shin MR,Sesti F

更新日期：2019-05-14 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the formation of extracellular amyloid plaques containing the amyloid β-protein (Aβ) within the parenchyma of the brain. Aβ42, which is 42 amino acids in length, is considered to be the key pathogenic factor in AD. Iron deposition is found abundantly in the amyloid plaques ...

journal_title：Biochemical and biophysical research communications

authors： Shen X,Liu J,Fujita Y,Liu S,Maeda T,Kikuchi K,Obara T,Takebe A,Sayama R,Takahashi T,Matsue A,Sera K,Michikawa M,Komano H,Zou K

更新日期：2019-05-14 00:00:00

abstract：:l-Ornithine is found in animals as a free amino acid and is a vital component of the urea cycle in the liver; it is reported to have various functions such as promoting wound healing, promoting growth hormone secretion, hypnotic effects, and so on. The present study aimed to investigate the effects of a single oral ad...

journal_title：Biochemical and biophysical research communications

authors： Harada D,Nagamachi S,Aso K,Ikeda K,Takahashi Y,Furuse M

更新日期：2019-05-14 00:00:00

abstract：:Aminopeptidase B (Ap-B) is a Zn2+-aminopeptidase of the M1 family which is implicated, in conjunction with the nardilysin endoprotease, in the generation of miniglucagon, a peptide involved in the maintenance of glucose homeostasis. Other in vivo physiological roles have been established for this vertebrate enzyme, su...

journal_title：Biochemical and biophysical research communications

authors： Cadel S,Darmon C,Désert A,Mahbouli M,Piesse C,Ghélis T,Lafont R,Foulon T

更新日期：2019-05-14 00:00:00

abstract：:The cochlea in the mammalian inner ear is a sensitive and sharply organized sound-detecting structure. The proper specification of neurosensory-competent domain in the otic epithelium is required for the formation of mature neuronal and sensory domains. Genetic studies have provided many insights into inner ear develo...

journal_title：Biochemical and biophysical research communications

authors： Ma JH,Kim HP,Shin JO

更新日期：2019-05-14 00:00:00

abstract：:Baeyer-Villiger monooxygenase (BVMO) catalyzes insertion of an oxygen atom into aliphatic or cyclic ketones with high regioselectivity. The BVMOs from Parvibaculum lavamentivorans (BVMOParvi) and Oceanicola batsensis (BVMOOcean) are interesting because of their homologies, with >40% sequence identity, and reaction wit...

journal_title：Biochemical and biophysical research communications

authors： Nguyen TD,Choi GE,Gu DH,Seo PW,Kim JW,Park JB,Kim JS

更新日期：2019-05-07 00:00:00

abstract：:Here we integrate multiple Gaussian-functions analysis into fluorescence resonance energy transfer (FRET) two-hybrid assays (Gaussian FRET two-hybrid assay) to determine the stoichiometric ratios of intracellular hetero-oligomers in single living cells. This method adopts in multiple Gaussian-functions to fit the E-co...

journal_title：Biochemical and biophysical research communications

authors： Qu W,Du M,Yang F,Mai Z,Zhang C,Lin F,Ma Y,Chen T

更新日期：2019-05-07 00:00:00

abstract：:Cancer stem cells (CSCs) are a small population of cells with stem cell-like properties found in tumors. CSCs are closely associated with tumor heterogeneity, which influences tumor progress, metastasis, and drug resistance. Here, we propose a concept to enhance efficacy of cancer therapy through CSC reprogramming int...

journal_title：Biochemical and biophysical research communications

authors： Lee KS,Choi JS,Cho YW

更新日期：2019-05-07 00:00:00

abstract：:Oxidative stress is widely involved in pathophysiological processes of cardiac remodeling. Molecules associated with antioxidant functions may be ideal targets for reversing cardiac remodeling. Sestrin2 is the important component of endogenous antioxidant defense, while there is little information on the pathophysiolo...

journal_title：Biochemical and biophysical research communications

authors： Du JX,Wu JZ,Li Z,Zhang C,Shi MT,Zhao J,Jin MW,Liu H

更新日期：2019-04-30 00:00:00

abstract：:HERC2 is a giant protein with E3 ubiquitin ligase activity and other known and suspected functions. Mutations of HERC2 are implicated in the pathogenesis of various cancers and result in severe neurological conditions in Herc2-mutant mice. Recently, a pleotropic autosomal recessive HERC2-associated syndrome of intelle...

journal_title：Biochemical and biophysical research communications

authors： Abraham JR,Barnard J,Wang H,Noritz GH,Yeganeh M,Buhas D,Natowicz MR

更新日期：2019-04-30 00:00:00

abstract：:Comprehensive knowledge on the murine CT26 colon carcinoma line is a classic model used in the pharmacodynamic experiments involving IDO-1 inhibitors, immune-related checkpoint antibodies and immune related mechanisms. In this study, we determined the impact of different subcutaneous inoculation locations on tumor gro...

journal_title：Biochemical and biophysical research communications

authors： Fu X,Yang Y,Xie J,Pan X,Yang X,Du Z,Hao E

更新日期：2019-04-30 00:00:00